David Moyes makes his return to management while North London braces itself for derby night as part of an enthralling four-match Premier League card on Wednesday.
Goodison Park will be rocking as it welcomes Moyes back as manager, though the Scot has a tough baptism with Aston Villa the visitors to Merseyside.
Leicester take on Crystal Palace in a crunch relegation clash while Newcastle hope to strengthen their top-four claims by seeing off Wolves at St James' Park.
And then it's all eyes on The Emirates Stadium where Arsenal and Tottenham meet in an unmissable North London derby.
- ASTON VILLA TO BEAT EVERTON
- ANTHONY GORDON ANYTIME SCORER - NEWCASTLE VS WOLVES
- LEICESTER OR DRAW DOUBLE CHANCE VS CRYSTAL PALACE
- ARSENAL VS TOTTENHAM - OVER 5.5 CARDS
Bet On The Premier League
Everton vs Aston Villa
Aston Villa ruined Graham Potter's return to management on Friday and five days later they can do the same to David Moyes.
Potter's first game in charge of West Ham was a 2-1 loss at Aston Villa in the FA Cup third round and now Unai Emery's men head to Goodison determined to wreck Moyes' homecoming.
The Scot, who left Everton in 2013, returns with the club struggling to score goals and Villa look ideally equipped to make it a losing start for Moyes.
Goodison will be rocking and the Toffees will doubtless come out firing - but if Villa can weather the early storm then they possess the firepower that the hosts patently lack and that should prove the difference.
Everton are showing plenty of fight - they have drawn nine of their last 16 in all competitions, including a trio of December stalemates against Arsenal, Chelsea and Manchester City.
Since then, however, they have suffered a 2-0 home defeat by Nottingham Forest and a 1-0 reverse at Bournemouth before beating League One strugglers Peterborough 2-0 in the FA Cup.
In the league, they have failed to score in eight of their last ten. In Villa's last nine games they have scored 16 times and Emery is spoiled for choice with Jhon Duran back from a ban to contest the No.9 spot with Ollie Watkins.
ASTON VILLA TO BEAT EVERTON
Newcastle vs Wolves
Eddie Howe is desperately hoping hot-shot Alexander Isak is fit to line up against Wolves as Newcastle go in search of a remarkable ninth-straight win.
The Swede has scored 14 goals since the end of October and is on an incredible seven-game scoring streak in the Premier League.
Isak is struggling to be fit but Howe has plenty of other hitmen in form, none more than Anthony Gordon who is taken to find the net against Wolves.
Gordon has scored in each of his last three matches, has seven for the season, and is maturing into an absolute superstar at Tyneside with an improved eye for goal.
He will get chances against Wolves, who went into this round of fixtures with the worst defence in the top division, having shipped 45 goals in 20 games.
Admittedly most of those were under Gary O'Neil's watch and new boss Vitor Pereira began his reign with clean-sheet wins over Leicester and Manchester United. However, since then Wolves have drawn 2-2 at Spurs and lost 3-0 at home to Nottingham Forest.
Howe insists Wolves are improvers under Pereira but they still look fragile at the back and that's something the Toon, and Gordon in particular, can exploit.
ANTHONY GORDON ANYTIME SCORER
Leicester vs Crystal Palace
Ruud van Nistelrooy will be hoping Saturday's FA Cup demolition of QPR will set them up nicely for the visit of Crystal Palace.
The Foxes had lost five in a row in the Premier League to slip down to 19th in the table. The last three of those, however, were against Liverpool, Manchester City and Aston Villa, so perhaps those losses were not unexpected.
Van Nistelrooy will have been delighted to see his team respond by crushing Championship opponents QPR 6-2 at the weekend.
And while he's acutely aware that a full-strength Palace are a massive step up from a half-strength Hoops, scoring goals and winning games can only lift spirits.
Palace have lost only three times since the end of October but it is because they have drawn so many - six of their last 11 in the league and nine overall - that they are struggling to pull clear of the relegation places.
One of those draws was the 2-2 these teams played out at Selhurst Park in September and it would be no surprise if that wasn't every bit as tight.
Palace are probably short enough at odds-on with Leicester taken to avoid defeat.
LEICESTER OR DRAW DOUBLE CHANCE
Arsenal vs Tottenham
The big game of the night is the North London derby at the Emirates Stadium where, as usual, seriously high stakes are riding on the outcome.
Local bragging rights are obvious, but this game is far bigger given both sides are desperately in need of the victory.
Arsenal are without a win in three, losing ground in the title race, getting knocked out of the FA Cup and now with an EFL Cup final place looking unlikely following last week's 2-0 home loss to Newcastle in the first leg of their semi-final.
Tottenham have had just three 90-minute wins in their last 13 outings, culminating in Sunday's torturous extra-time success at non-league Tamworth in the FA Cup.
With that as the backdrop, expect a degree of desperation, no end of passion and the likelihood that referee Simon Hooper will be an extremely busy man.
When these sides met at the Tottenham Hotspur Stadium in September - a 1-0 win to Arsenal - there were eight yellow cards shown, all before the 49th minute.
Arsenal ought to win, there ought to be goals, and it's hard to believe there won't be a rash of cards shown.
OVER 5.5 CARDS
